|
KMID : 0624620170500040214
|
|
BMB Reports
2017 Volume.50 No. 4 p.214 ~ p.219
|
|
|
microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
|
|
Lee Hee-Jin
Tak Hyo-Sun
Park So-Jung
Jo Yoon-Kyung
Cho Dong-Hyung
Lee Eun-Kyung
|
|
|
Abstract
|
|
|
|
Mitochondria play pivotal roles in the ATP production, apoptosis and generation of reactive oxygen species. Although dynamic regulation of mitochondria morphology is a critical step to maintain cellular homeostasis, the regulatory mechanisms are not yet fully elucidated. In this study, we identified miR-200a-3p as a novel regulator of mitochondrial dynamics by targeting mitochondrial fission factor (MFF). We demonstrated that the ectopic expression of miR-200a-3p enhanced mitochondrial elongation, mitochondrial ATP synthesis, mitochondrial membrane potential and oxygen consumption rate. These results indicate that miR-200a-3p positively regulates mitochondrial elongation by downregulating MFF expression.
|
|
|
KEYWORD
|
|
|
microRNAs, miR-200a-3p, Mitochondria dynamics, Mitochondria fragmentation, Mitochondrial fission factor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|